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ICAMA No. PD20142441

Product Name: FLUMIOXAZIN

CAS: 103361-09-7

Toxicity: LD50 in rats (mg/kg): >5000 orally; >2000 dermally; LC50 (4 hr) in rats (mg/m3): >3930 by inhalation; LC50 (96 hr) in bluegill, rainbow trout (mg/l): >21, 2.3 (Yoshida).

Description: FLUMIOXAZIN is a benzoxazinones-type herbicide used on soybeans, peanuts, orchard fruits and other crop. It is a diphenyl ether group G herbicide that functioning through inhibiting the protoorphyrinogen oxidase. As a light-dependent peroxidising herbicide (LDPH), it takes effect by blocking heme and chlorophyll biosynthesis resulting in the accumulation of phototoxic porphyrins, leading to the membrane damage and further killing the weeds.

Uses: Herbicide.

Metabolic pathway: When the rats are given a single oral dose of 14C-S- 53482, seven metabolites are identified in the urine and the feces. Alcohol derivatives and the acetoanilide derivative are isolated from the urine, and three sulfonic acid conjugates with a sulfonic acid group incorporated into the double bond of the 3,4,5,6- tetrahydrophthalimide moiety are isolated from the feces.